| AstraZeneca | AstraZeneca | multiple | 1999 | $178,000,000 | | MEGADEAL  |
| Delaware City Refining Company | PBF Energy | state | 2010 | $20,000,000 | | grant/loan hybrid program |
| Bloom Energy | Bloom Energy | state | 2011 | $16,500,000 | | grant/loan hybrid program |
| Fisker Automotive | Wanxiang | state | 2010 | $12,500,000 | | grant/loan hybrid program |
| Delaware City Refining Company | PBF Energy | state | 2011 | $12,000,000 | | grant/loan hybrid program |
| Incyte Corporation | Incyte Corp. | state | 2012 | $11,120,505 | | grant/loan hybrid program |
| JP Morgan Chase Bank NA | JPMorgan Chase | state | 2015 | $10,500,000 | | grant/loan hybrid program |
| Chase Bank USA, National Association | JPMorgan Chase | state | 2012 | $10,140,000 | | grant/loan hybrid program |
| Ashland, Inc. | Ashland Global Holdings | state | 2012 | $10,000,000 | | grant/loan hybrid program |
| Delaware City Refining Company | PBF Energy | state | 2012 | $10,000,000 | | grant/loan hybrid program |
| E.I. DuPont Nemours and Co. | DuPont de Nemours | state | 2016 | $9,600,000 | | grant/loan hybrid program |
| Fisker Automotive | Wanxiang | state | 2010 | $9,000,000 | | grant/loan hybrid program |
| The Chemours Company | Chemours | state | 2016 | $7,897,081 | | grant/loan hybrid program |
| Discover Bank | Discover Financial Services | state | 2011 | $7,387,000 | | grant/loan hybrid program |
| Sallie Mae Inc. | Navient | state | 2011 | $5,105,440 | | grant/loan hybrid program |
| Limted Investment for Financial Traction | | state | 2009 | $5,000,000 | | grant/loan hybrid program |
| Delaware Innovation Space, Inc. | | state | 2017 | $5,000,000 | | grant/loan hybrid program |
| Amazon.com Services, LLC | Amazon.com | state | 2020 | $4,500,000 | | grant |
| Nanticoke Memorial Hospital | | state | 2009 | $4,489,729 | | grant/loan hybrid program |
| 21st Century North America Insurance Co | | state | 2014 | $4,339,265 | | grant/loan hybrid program |
| Solenis LLC | | state | 2019 | $3,913,050 | | grant |
| NP Delaware City Industrial, LLC | | state | 2020 | $3,900,000 | | grant |
| SLM Corp/BankCo | | state | 2014 | $3,719,740 | | grant/loan hybrid program |
| Amazon.com.dedc LLC | Amazon.com | state | 2011 | $3,472,500 | | grant/loan hybrid program |
| Datwyler Pharma Packaging USA Inc. | | state | 2016 | $3,128,715 | | grant/loan hybrid program |
| Citicorp Credit Services, Inc. | Citigroup | state | 2011 | $3,000,000 | | grant/loan hybrid program |
| Delaware State University | | state | 2014 | $3,000,000 | | grant/loan hybrid program |
| Delaware Technology Park | | state | 2015 | $3,000,000 | | grant/loan hybrid program |
| Fraunhofer USA, Inc. Center for Molecular Biotechnology | | state | 2011 | $3,000,000 | | grant/loan hybrid program |
| Zenbanx | | state | 2016 | $2,940,000 | | grant/loan hybrid program |
| Energizer Holdings, Inc. | Energizer | state | 2015 | $2,932,409 | | grant/loan hybrid program |
| Perdue AgriBusiness LLC. | Perdue | state | 2016 | $2,831,363 | | grant/loan hybrid program |
| Marlette Funding | | state | 2019 | $2,725,000 | | grant |
| Barclays Bank Delaware | Barclays | state | 2020 | $2,495,470 | | grant |
| Croda, Inc. | | state | 2015 | $2,487,384 | | grant/loan hybrid program |
| Johnson Controls Battery Group, Inc. | Brookfield Asset Management | state | 2011 | $2,445,668 | | grant/loan hybrid program |
| CIGNA | Cigna | state | 2010 | $2,365,238 | | grant/loan hybrid program |
| Sallie Mae Bank | SLM Corp. | state | 2018 | $2,160,000 | | grant |
| Navient | Navient | state | 2014 | $1,920,165 | | grant/loan hybrid program |
| Proximity Malt | | state | 2016 | $1,733,575 | | grant/loan hybrid program |
| FMC Corporation | FMC Corp. | state | 2019 | $1,642,500 | | grant |
| Johnson Controls Battery Group, Inc. | Brookfield Asset Management | state | 2016 | $1,635,395 | | grant/loan hybrid program |
| Pioneer Hi-Bred International, Inc. | Corteva | state | 2011 | $1,500,000 | | grant/loan hybrid program |
| JPMorgan Chase Bank, N.A. | JPMorgan Chase | state | 2014 | $1,500,000 | | grant/loan hybrid program |
| Nanticoke Memorial Hospital | | state | 2014 | $1,500,000 | | grant/loan hybrid program |
| Wells Fargo Bank, National Association | Wells Fargo | state | 2015 | $1,385,025 | | grant/loan hybrid program |
| Summit Aviation, Inc. | | state | 2009 | $1,369,727 | | grant/loan hybrid program |
| Perdue Foods, LLC | Perdue | state | 2014 | $1,300,000 | | grant/loan hybrid program |
| Nanticoke Memorial Hospital | | state | 2011 | $1,250,000 | | grant/loan hybrid program |
| M Cubed Technologies Inc. | II-VI Inc. | state | 2017 | $1,245,714 | | grant/loan hybrid program |
| Alpha Technologies USA, Inc | | state | 2015 | $1,226,888 | | grant/loan hybrid program |
| Service Telecom/Activair (Assumption of Advanced Aerosol) | | state | 2011 | $1,200,000 | | grant/loan hybrid program |
| Nationwide Healthcare Services | | state | 2019 | $1,198,000 | | grant |
| The Kraft Heinz Company | Kraft Heinz | state | 2016 | $1,181,130 | | grant/loan hybrid program |
| GE Aviation | General Electric | state | 2013 | $1,114,833 | | grant/loan hybrid program |
| Hologic, Inc. | Hologic | state | 2012 | $1,111,800 | | grant/loan hybrid program |
| Dot Foods | Dot Foods | state | 2019 | $1,102,000 | | grant |
| Solenis, LLC | | state | 2015 | $1,100,397 | | grant/loan hybrid program |
| Springleaf General Services Corp | | state | 2013 | $1,089,351 | | grant/loan hybrid program |
| SevOne, Inc. | | state | 2015 | $1,046,480 | | grant/loan hybrid program |
| E. I. DuPont De Nemours and Company, Inc. (Project Mercury) | DuPont de Nemours | state | 2012 | $920,000 | | grant/loan hybrid program |
| Del Monte Fresh Produce NA, Inc. | Fresh Del Monte Produce | state | 2017 | $913,000 | | grant/loan hybrid program |
| Barclays Bank Delaware | Barclays | state | 2009 | $900,000 | | grant/loan hybrid program |
| Zacros America, Inc. | | state | 2015 | $883,505 | | grant/loan hybrid program |
| InterDigital, Inc. | Interdigital Inc. | state | 2012 | $850,000 | | grant/loan hybrid program |
| Prelude Therapuetics Incorporated | | state | 2020 | $834,090 | | grant |
| Mountaire Farms of Delaware, Inc. | Mountaire Corporation | state | 2010 | $787,500 | | grant/loan hybrid program |
| Fair Square Financial LLC | | state | 2017 | $779,025 | | grant/loan hybrid program |
| Cohesive Strategies, Inc. | | state | 2016 | $763,775 | | grant/loan hybrid program |
| Hawker Beechcraft Global Customer Support Corporation | Textron | state | 2011 | $750,000 | | grant/loan hybrid program |
| Sanosil | | state | 2009 | $750,000 | | grant/loan hybrid program |
| Sun Behavioral Health | | state | 2016 | $708,367 | | grant/loan hybrid program |
| Wilmington PharmaTech Company | | state | 2019 | $660,400 | | grant |
| PTM | | state | 2009 | $645,000 | | grant/loan hybrid program |
| M&T Bank Corporation | M&T Bank | state | 2012 | $627,900 | | grant/loan hybrid program |
| Modular Carpet Recycling | | state | 2009 | $604,304 | | grant/loan hybrid program |
| New ILC Dover (Grayling) | | state | 2013 | $552,360 | | grant/loan hybrid program |
| DEMEP | | state | 2018 | $518,380 | | grant |
| DEDO/Amtrak | | state | 2011 | $500,000 | | grant/loan hybrid program |
| RLDP Holdings, LP | | state | 2010 | $500,000 | | grant/loan hybrid program |
| Testing Machines, Inc. | | state | 2009 | $500,000 | | grant/loan hybrid program |
| DEDO | | state | 2009 | $500,000 | | grant/loan hybrid program |
| Information Assurance Corporation, Inc. | | state | 2009 | $500,000 | | grant/loan hybrid program |
| Coastal Brewing Company, LLC | | state | 2009 | $500,000 | | grant/loan hybrid program |
| Collections Marketing Services, LLC | | state | 2009 | $500,000 | | grant/loan hybrid program |
| B. F. Rich Co., Inc. | | state | 2012 | $500,000 | | grant/loan hybrid program |
| CD Diagnostics, Inc. | | state | 2012 | $500,000 | | grant/loan hybrid program |
| Computer Aid, Inc. | | state | 2011 | $500,000 | | grant/loan hybrid program |
| Delaware Biotechnology Institute (U of D) | | state | 2014 | $500,000 | | grant/loan hybrid program |
| West End Neighborhood House | | state | 2018 | $500,000 | | grant |
| First State Community Loan Fund | | state | 2018 | $500,000 | | grant |
| SevOne, Inc. | | state | 2012 | $484,218 | | grant/loan hybrid program |
| Bayhealth Medical Center, Inc. | | state | 2014 | $481,309 | | grant/loan hybrid program |
| Prelude Therapeutics Inc. | | state | 2018 | $474,491 | | grant |
| Platinum Hanger, LLC | | state | 2009 | $470,490 | | grant/loan hybrid program |
| Frontier Scientific, Inc | | state | 2015 | $469,092 | | grant/loan hybrid program |
| United Parcel Service, Inc. | United Parcel Service | state | 2016 | $465,000 | | grant/loan hybrid program |
| Kraft Foods Group, Inc. | Kraft Heinz | state | 2012 | $456,000 | | grant/loan hybrid program |
| Adesis Inc. | | state | 2018 | $445,224 | | grant |
| Berkley Technology Services LLC | | state | 2011 | $433,568 | | grant/loan hybrid program |
| General Refrigeration Company | | state | 2018 | $433,500 | | grant |
