| Proximity Malt | | state | 2016 | $1,733,575 | | grant/loan hybrid program |
| Proximity Malt, LLC | | state | 2016 | $100,000 | | grant |
| Pryme Styles & Cuts Unisex Salon | | state | 2020 | | $1,831 | loan |
| PTHERA, LLC | | state | 2020 | $100,000 | | grant |
| PTM | | state | 2009 | $645,000 | | grant/loan hybrid program |
| Pusan LLC | | state | 2020 | | $29,995 | loan |
| Qualicon | DuPont de Nemours | state | 2002 | $1,957 | | training reimbursement |
| Quantum Leap Innovations, Inc. | | state | 2011 | $50,000 | | grant/loan hybrid program |
| Quest Pharmaceutical | | state | 2005 | $21,830 | | training reimbursement |
| Quest Pharmaceutical Services | | state | 2004 | $3,600 | | training reimbursement |
| Quest Pharmaceutical Services | | state | 2006 | $16,460 | | training reimbursement |
| Quest Pharmaceutical Services | | state | 2006 | $4,320 | | training reimbursement |
| Quintus Group LLC | | state | 2020 | | $6,641 | loan |
| Quip Laboratories Incorporated | | state | 2015 | $14,472 | | training reimbursement |
| Rasa Sayang Corporation | | state | 2020 | | $13,478 | loan |
| Rath Incorporated | | state | 2008 | $6,125 | | training reimbursement |
| Rath Performance Fibers | | state | 2004 | $1,229 | | training reimbursement |
| Raw Essential LLC | | state | 2020 | | $3,433 | loan |
| Ray Tull | | state | 2016 | | $17,619 | loan |
| RB Azafran Inc | | state | 2020 | | $5,793 | loan |
| RB Gyms Inc | | state | 2020 | | $10,000 | loan |
| Real Entertainment - Wilmington, LLC | | state | 2011 | $250,000 | | grant/loan hybrid program |
| Real Global Group LLC | | state | 2016 | | $54,000 | loan |
| Red Square International Inc | | state | 2020 | | $9,036 | loan |
| REH Enterprises Inc | | state | 2020 | | $1,896 | loan |
| Rehoboth Lobster Co LLC | | state | 2020 | | $10,000 | loan |
| Rehoboth Nails & Spa | | state | 2020 | | $4,389 | loan |
| Rehoboth Water Ice | | state | 2018 | $12,500 | | grant |
| Resource International, Inc | | state | 2015 | $119,925 | | grant/loan hybrid program |
| Resources International. Inc. | | state | 2012 | $81,143 | | grant/loan hybrid program |
| Retired-N-Fit | | state | 2019 | $29,750 | | grant |
| RiKarbon | | state | 2019 | $50,000 | | grant |
| Risen Services, LLC | | state | 2018 | $10,625 | | grant |
| River Lights Café LLC | | state | 2020 | | $3,251 | loan |
| River Road Swim Club | | state | 2020 | | $3,280 | loan |
| RLDP Holdings, LP | | state | 2010 | $500,000 | | grant/loan hybrid program |
| Robert Emerson | | state | 2020 | | $8,203 | loan |
| Robert Emerson II | | state | 2020 | | $8,526 | loan |
| Robert J. Peoples | | state | 2010 | $1,500 | | training reimbursement |
| Rogers Corporation (pka Arlon) | | state | 2016 | $26,359 | | training reimbursement |
| Rogers Corporation (pka Arlon) | | state | 2016 | $28,652 | | training reimbursement |
| Romer Labs Technology, Inc. | | state | 2016 | $17,978 | | training reimbursement |
| Romer Labs Technology, Inc. | | state | 2017 | $18,025 | | training reimbursement |
| Romer Labs Technology, Inc. | | state | 2018 | $3,690 | | grant |
| Romer Labs Technology, Inc.-Six Sigma Consortia | | state | 2016 | $3,690 | | training reimbursement |
| Rose Nails | | state | 2020 | | $2,526 | loan |
| Route 113 Associates, LLC | | state | 2009 | $63,212 | | grant/loan hybrid program |
| Route 202 Group LLC | | state | 2020 | | $46,650 | loan |
| Roxana Artisans Market | | state | 2015 | $4,063 | | grant |
| Roy McIntyre, III d/b/a Delaware Detailing, Inc. | | state | 2015 | $7,000 | | grant |
| Royal Martin Inc | | state | 2020 | | $6,870 | loan |
| RP Hospitality LLC | | state | 2020 | | $4,472 | loan |
| RST Markets LTD | | state | 2020 | | $3,564 | loan |
| Ryerson | Platinum Equity | state | 2013 | $21,951 | | training reimbursement |
| Ryerson | Platinum Equity | state | 2014 | $16,317 | | training reimbursement |
| Sahazkids LLC | | state | 2020 | | $7,259 | loan |
| Sairam LLC | | state | 2020 | | $10,000 | loan |
| Sallie Mae Bank | SLM Corp. | state | 2018 | $2,160,000 | | grant |
| Sallie Mae Corporation | Navient | state | 2009 | $100,000 | | training reimbursement |
| Sallie Mae Corporation | Navient | state | 2009 | $99,810 | | training reimbursement |
| Sallie Mae Corporation | Navient | state | 2009 | $100,000 | | training reimbursement |
| Sallie Mae Inc. | Navient | state | 2011 | $5,105,440 | | grant/loan hybrid program |
| Salon 828 | | state | 2020 | | $5,000 | loan |
| Salon Essence LLC | | state | 2020 | | $3,300 | loan |
| Samovar Group, LLC | | state | 2020 | $7,500 | | grant |
| Sandy Wellness Center Inc | | state | 2020 | | $1,897 | loan |
| Sanosil | | state | 2009 | $750,000 | | grant/loan hybrid program |
| SAS Nanotechnologies | | state | 2019 | $50,000 | | grant |
| Saudades Grp | | state | 2020 | | $20,000 | loan |
| Savannah 330 | | state | 2020 | | $5,090 | loan |
| Savvy Hair Studio | | state | 2020 | | $2,289 | loan |
| Schering-Plough Animal Health Corporation | Merck | state | 2006 | $21,485 | | training reimbursement |
| Schering-Plough Animal Health Corporation | Merck | state | 2007 | $43,943 | | training reimbursement |
| Schering-Plough Animal Health Corporation | Merck | state | 2008 | $45,400 | | training reimbursement |
| Sea Watch International | | state | 2011 | $24,291 | | training reimbursement |
| Seascape Health Alliance, LLC | | state | 2016 | $20,000 | | grant |
| Seascape Health Alliance, LLC | | state | 2017 | $12,500 | | grant |
| Sedona Restaurant LLC | | state | 2020 | | $5,735 | loan |
| Sepax Technologies, Inc | | state | 2016 | $12,798 | | training reimbursement |
| Service General Corp. | | state | 2003 | $6,145 | | training reimbursement |
| Service Telecom/Activair (Assumption of Advanced Aerosol) | | state | 2011 | $175,000 | | grant/loan hybrid program |
| Service Telecom/Activair (Assumption of Advanced Aerosol) | | state | 2011 | $1,200,000 | | grant/loan hybrid program |
| SevOne | | state | 2014 | $100,000 | | training reimbursement |
| SevOne | | state | 2015 | $71,600 | | training reimbursement |
| SevOne | | state | 2016 | $21,000 | | training reimbursement |
| SevOne, Inc. | | state | 2011 | $77,731 | | training reimbursement |
| SevOne, Inc. | | state | 2012 | $484,218 | | grant/loan hybrid program |
| SevOne, Inc. | | state | 2015 | $1,046,480 | | grant/loan hybrid program |
| Seztex Inc | | state | 2020 | | $93,636 | loan |
| Seztex Inc. | | state | 2003 | $16,246 | | training reimbursement |
| Sharky's Grill & BBQ | | state | 2020 | | $17,500 | loan |
| Shaw Global Energy Services | McDermott International | state | 2003 | $4,329 | | training reimbursement |
| Shaw Global Energy Services | McDermott International | state | 2003 | $2,184 | | training reimbursement |
| Shawn Hanley | | state | 2020 | | $1,500 | loan |
| Sheraton Dover Hotel | Marriott International | state | 2000 | $3,058 | | training reimbursement |
| Sheraton Dover Hotel | Marriott International | state | 2001 | $13,727 | | training reimbursement |
| Shipfitter Park LLC | | state | 2020 | | $350,000 | loan |
| Shiv Sagar | | state | 2020 | | $10,000 | loan |
| Shore Star LLC | | state | 2020 | | $4,800 | loan |
| Shoreline Vinyl Systems, Inc. | | state | 2020 | $10,350 | | grant |
| Shree Kishna Inc | | state | 2020 | | $20,000 | loan |
