| Shire HGT, Inc. | Massachusetts | state | 2011 | $5,855,368 | | tax credit/rebate |
| Takeda Pharmaceuticals North America, Inc. | Illinois | state | 2009 | $4,511,785 | | tax credit/rebate |
| NPS Pharmaceuticals, Inc. | New Jersey | state | 2003 | $4,371,200 | | grant |
| Shire HGT, Inc. | Massachusetts | state | 2011 | $3,500,000 | | tax credit/rebate |
| Shire Human Genetic Therapies, Inc | Massachusetts | state | 2012 | $3,000,000 | | tax credit/rebate |
| Takeda Pharmaceuticals North America, Inc. | Illinois | state | 2008 | $2,034,824 | | tax credit/rebate |
| Shire Pharmaceuticals, Inc. | Pennsylvania | state | | $2,000,000 | | grant |
| Takeda Pharmaceuticals North America, Inc. | Illinois | state | 2006 | $1,384,120 | | tax credit/rebate |
| Baxalta. Inc. | Massachusetts | state | 2016 | $1,320,000 | | tax credit/rebate |
| ARIAD Pharmaceuticals, Inc. | Massachusetts | state | 2013 | $1,225,000 | | tax credit/rebate |
| Shire Holdings US, AG | Pennsylvania | state | 2015 | $1,223,167 | | tax credit/rebate |
| Shire Pharmaceuticals, Inc. | Pennsylvania | state | | $1,200,000 | | tax credit/rebate |
| Takeda Pharmaceuticals America, Inc. | Massachusetts | state | 2016 | $1,125,000 | | tax credit/rebate |
| Takeda Pharmaceuticals North America, Inc. | Illinois | state | 2009 | $1,105,019 | | tax credit/rebate |
| Shire Human Genetic Therapies | Massachusetts | state | 2015 | $985,000 | | tax credit/rebate |
| Takeda Pharmaceuticals North America, Inc. | Illinois | state | 2005 | $952,634 | | tax credit/rebate |
| Shire US Holdings, Inc. | Pennsylvania | state | 2014 | $914,646 | | tax credit/rebate |
| Shire Human Genetic Therapies, Inc. | Massachusetts | state | 2013 | $750,000 | | tax credit/rebate |
| Shire Holdings US, AG | Pennsylvania | state | 2016 | $621,710 | | tax credit/rebate |
| Shire Human Genetic Therapies | Massachusetts | state | 2014 | $597,076 | | tax credit/rebate |
| Shire Holdings US, AG | Maryland | state | 2004 | $588,423 | | tax credit/rebate |
| BioLife Plasma Services L.P. | Idaho | state | 2011 | $523,620 | | training reimbursement |
| Viropharma Incorporated | Pennsylvania | state | | $453,000 | | tax credit/rebate |
| Shire Pharmaceuticals Inc. | Pennsylvania | state | 2008 | $402,051 | | tax credit/rebate |
| Takeda Pharmaceuticals North America, Inc. | Illinois | state | 2006 | $350,000 | | grant |
| Takeda Pharmaceuticals North America, Inc. | Illinois | state | 2007 | $350,000 | | grant |
| Shire ViroPharma Incorporated | Pennsylvania | state | 2015 | $312,596 | | tax credit/rebate |
| Shire Human Genetic Therapies Inc | Pennsylvania | state | 2021 | $294,400 | | tax credit/rebate |
| Shire US Holdings, Inc. | Pennsylvania | state | 2013 | $255,775 | | tax credit/rebate |
| Shire Pharmaceuticals, Inc. | Pennsylvania | state | 2009 | $246,912 | | tax credit/rebate |
| Shire Pharmaceuticals, Inc. | Pennsylvania | state | 2010 | $228,422 | | tax credit/rebate |
| Shire Human Genetic Therapies, Inc. | Pennsylvania | state | 2017 | $160,094 | | tax credit/rebate |
| SHIRE HUMAN GENETIC THERAPIES INC | Pennsylvania | state | 2020 | $121,300 | | tax credit/rebate |
| Shire Human Genetic Therapies, Inc. | Pennsylvania | state | 2016 | $118,253 | | tax credit/rebate |
| Shire ViroPharma, Inc. | Pennsylvania | state | 2016 | $85,794 | | tax credit/rebate |
| Shire Human Genetic Therapies, Inc. | Pennsylvania | state | 2015 | $85,593 | | tax credit/rebate |
| Shire Holdings US, AG | Maryland | state | 2005 | $53,032 | | tax credit/rebate |
| Shire Holding US AG | Maryland | state | 2008 | $33,609 | | tax credit/rebate |
| Shire US Manufacturing, Inc. | Maryland | state | 2009 | $30,126 | | tax credit/rebate |
| Shire Holdings US AG | Maryland | state | 2007 | $27,738 | | tax credit/rebate |
| Shire US Manufacturing, Inc. | Maryland | state | 2004 | $26,595 | | training reimbursement |
| Shire US Manufacturing, Inc. | Maryland | state | 2008 | $24,791 | | training reimbursement |
| Shire US Manufacturing Inc. | Maryland | state | 2007 | $23,191 | | training reimbursement |
| Baxalta Us Inc | California | state | 2022 | $20,998 | | training reimbursement |
| Takeda Pharmaceuticals North America, Inc. | Illinois | state | 2005 | undisclosed | | tax credit/rebate |
| Takeda Pharmaceuticals North America, Inc. | Illinois | state | 2006 | undisclosed | | tax credit/rebate |
| Takeda Pharmaceuticals North America, Inc. | Illinois | state | 2007 | undisclosed | | tax credit/rebate |
| Takeda Pharmaceuticals North America, Inc. | Illinois | state | 2007 | undisclosed | | tax credit/rebate |
| Takeda Pharmaceuticals North America, Inc. | Illinois | state | 2008 | undisclosed | | tax credit/rebate |
| Shire Human Genetics Therapies, Inc. | Massachusetts | state | 2007 | undisclosed | | tax credit/rebate |
| Takeda Pharmaceuticals America | West Virginia | state | 2010 | undisclosed | | tax credit/rebate |
